The Department of Chemistry started functioning as an independent department in Assam Don Bosco University, from 1st April 2018 onwards. Prior to this date, the department was serving as a constituent of the Department of Basic Sciences, teaching Chemistry courses to the undergraduate engineering students of the University.

Since July 2017 the department began offering a two-year (4-semester) MSc programme in Chemistry. From July 2018 onwards, the department began offering a three-year (six-semester) BSc Honours course in Chemistry with students opting for general electives in Physics and Math or Botany and Zoology.